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CADUET Is Clinically Proven

In one clinical study involving patients with high blood pressure and high cholesterol, CADUET® (amlodipine besylate/atorvastatin calcium), along with lifestyle changes, helped 48% of patients (30 out of 63) lower their blood pressure and cholesterol in just 4 weeks. Only 2% of patients (1 out of 59) taking a placebo pill and also making lifestyle changes lowered theirs.

Not all patients will reach their individual blood pressure and cholesterol goals as determined by their doctor. Individual results will vary.

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Who Should Not Use CADUET?

  • Anyone who has previously had an allergic reaction to CADUET or to any of the inactive ingredients
  • Women who are nursing, pregnant, or may become pregnant
  • Those with liver problems
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What Are the Possible Side Effects of CADUET?

CADUET may cause serious side effects. These side effects happen only to a small number of people. Your doctor can monitor you for them. These side effects usually go away if your dose is lowered or if CADUET is stopped. These serious side effects include:

  • Muscle problems—CADUET may cause serious muscle problems that can lead to kidney problems, including kidney failure. You have a higher chance of getting muscle problems if you are taking certain other medicines with CADUET
  • Liver problems—CADUET may cause liver problems. Your doctor should do blood tests to check your liver function before starting CADUET and during your treatment if you have symptoms of liver problems
  • Low blood pressure or dizziness
  • Muscle rigidity, tremor, and/or abnormal muscle movement

Are There Other Common Side Effects of CADUET?

Common side effects of CADUET include:

  • Nausea
  • Upset stomach
  • Diarrhea
  • Swelling of your legs or ankles (edema)
  • Muscle and joint pain
  • Alterations in some laboratory blood tests

Additional side effects have been reported: tiredness, tendon problems, memory loss, and confusion. Talk to your doctor or pharmacist about side effects that bother you or do not go away.

There are other side effects of CADUET. Ask your doctor or pharmacist for a complete list.

Important Safety Information

CADUET® (amlodipine besylate/atorvastatin calcium) tablets are not for everyone, including anyone who has previously had an allergic reaction to CADUET or to any of the inactive ingredients. It is not for those with liver problems. And it is not for women who are nursing, pregnant, or may become pregnant.

If you take CADUET, tell your doctor if you feel any new muscle pain or weakness. This could be a sign of rare but serious muscle side effects that can lead to kidney problems, including kidney failure. Tell your doctor about all your medical conditions and all medications you take. This may help avoid serious drug interactions. Your doctor should do blood tests to check your liver function before starting CADUET and during your treatment if you have symptoms of liver problems.

If you have had any heart problems, be sure to tell your doctor. It is rare, but when you first start taking the amlodipine component of CADUET or increase your dose, you may have a heart attack or your angina may get worse. If that happens, call your doctor right away or go directly to a hospital emergency room.

Tell your doctor if you have diabetes. Elevated blood sugar levels have been reported with statins, including the atorvastatin component of CADUET.

Serious side effects of CADUET include muscle problems, kidney problems and low blood pressure or dizziness.

Common side effects include swelling of your legs or ankles, dizziness, tiredness, extreme sleepiness, nausea, flushing (hot or warm feeling in your face), arrhythmia (irregular heartbeat), heart palpitations (very fast heartbeat), diarrhea, upset stomach, muscle and joint pain, and changes in some blood tests.


CADUET® (amlodipine besylate/atorvastatin calcium) tablets are a prescription drug that combines two medicines, NORVASC® (amlodipine besylate) and LIPITOR® (atorvastatin calcium) tablets. CADUET is used in adults who need both NORVASC and LIPITOR.

NORVASC® (amlodipine besylate) is prescribed to treat high blood pressure (hypertension), chest pain (angina) and blocked arteries of the heart (coronary artery disease). NORVASC can be used by itself or with other medicines that treat high blood pressure.

LIPITOR® (atorvastatin calcium) is used along with a low-fat diet to lower the LDL (“bad” cholesterol) and triglycerides in the blood. It can raise the HDL (“good” cholesterol) as well. LIPITOR is used to lower the risk of heart attack, stroke, certain types of heart surgery, and chest pain in patients who have heart disease or risk factors for heart disease such as age, smoking, high blood pressure, low HDL, or family history of early heart disease.

LIPITOR can also lower the risk of heart attack or stroke in patients with diabetes and risk factors such as diabetic eye or kidney problems, smoking, or high blood pressure.

CADUET is one of many options for treating high blood pressure and high cholesterol, in addition to diet and exercise that you and your doctor can consider.

Please see Full Prescribing Information and Patient Information.

Patients should always ask their doctors for medical advice about adverse events.

You may report an adverse event related to Pfizer products by calling 1-800-438-1985 (US only). If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. The FDA has established a reporting service known as MedWatch where health care professionals and consumers can report serious problems they suspect may be associated with the drugs and medical devices they prescribe, dispense, or use.Visit MedWatch or call 1-800-FDA-1088.

*Terms and Conditions

By using the CADUET Savings Card, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:

  • The Card is not valid for prescriptions that are eligible to be reimbursed, in whole or in part, by Medicaid, Medicare, or other federal or state healthcare programs (including any state prescription drug assistance programs and the Government Health Insurance Plan available in Puerto Rico [formerly known as “La Reforma De Salud”])
  • The Card is not valid for prescriptions that are eligible to be reimbursed by private insurance plans or other health or pharmacy benefit programs that reimburse you for the entire cost of your prescription drugs
  • Patients must be 18 or older
  • By using the Card, patients may pay a minimum of $4 per refill and receive savings of up to $150 per refill. The Card is good for a maximum savings of $1800 per calendar year
  • You must deduct the value received under this program from any reimbursement request submitted to your insurance plan, either directly by you or on your behalf
  • The Card is not valid for Massachusetts residents whose prescriptions are covered in whole or in part by third-party insurance, or where otherwise prohibited by law
  • The Card cannot be combined with any other rebate or coupon, free trial, or similar offer for the specified prescription
  • The Card will be accepted only at participating pharmacies
  • The Card is not health insurance
  • This offer is good only in the United States and Puerto Rico
  • The Card is limited to one per person during this offering period and is not transferable
  • Pfizer reserves the right to rescind, revoke, or amend the Card without notice
  • The Card expires on December 31, 2018. No membership fees apply

For help with the CADUET Savings Card, call 1-877-CADUET-4 (1-877-223-8384) or write: Pfizer, Attn: CADUET, PO Box 4932, Warren, NJ 07059-6600.

For reimbursement when using a non-participating pharmacy/mail order:

Pay for your CADUET prescription and mail copy of original pharmacy receipt (cash register receipt NOT valid) with product name, date, and amount circled to: Pfizer, ATTN: CADUET, PO Box 4932, Warren, NJ 07059-6600. Be sure to include a copy of the front of your CADUET Savings Card, your name, and mailing address. Please expect up to 4 to 6 weeks for reimbursement.

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